On the site of antitussive action of 1-(2-benzylphenoxy)-2-piperidinopropane phosphate (Pirexyl).
نویسندگان
چکیده
1-(2-Benzylphenoxy)-2-piperidinopropane phosphate (abbreviated as ASA 158/5) which was introduced by the Pharmacia Research Laboratory (Sweden) is a compound with the following chemical structure (1). According to an unofficial and unpublished report from the Laboratory (2), it has the antitussive potency 2 to 4 times as potent as that of codeine phosphate and its antitussive action may be mainly due to the prevention of impulses from the pulmonary stretch receptors. The present purpose of this study is to confirm the site of antitussive action of the drug.
منابع مشابه
Antitussive effect of RU-20201--central and peripheral actions.
The antitussive effect of the new compound 1, 2, 3, 4a, 9b-hexahydro-8, 9b-dimethyl-4-[3-(4-methyl-piperazine-1-yl) propionamide] dibenzofuran-3-one dihydrochloride (RU-20201) was investigated in dogs and guinea pigs, including its sites of action. The antitussive effect of RU-20201 was about 1/10 as potent as that of codeine phosphate in dogs with the puncture electrode-induced cough (PEC) met...
متن کاملDepression of cough reflex by microinjections of antitussive agents into caudal ventral respiratory group of the rabbit.
We have previously shown that the caudal nucleus tractus solitarii is a site of action of some antitussive drugs and that the caudal ventral respiratory group (cVRG) region has a crucial role in determining both the expiratory and inspiratory components of the cough motor pattern. These findings led us to suggest that the cVRG region, and possibly other neural substrates involved in cough regul...
متن کاملSuppression of the cough reflex by inhibition of ERK1/2 activation in the caudal nucleus tractus solitarii of the rabbit.
The caudal nucleus tractus solitarii (cNTS), the predominant site of termination of cough-related afferents, has been shown to be a site of action of some centrally acting antitussive agents. A role of ERK1/2 has been suggested in acute central processing of nociceptive inputs. Because pain and cough share similar features, we investigated whether ERK1/2 activation could also be involved in the...
متن کاملAntitussive activity of ethanolic extract of Curcuma aromatica rhizomes on sulfur dioxide induced cough in mice
Ethanolic extract of rhizomes of Curcuma aromatica (Zingiberaceae) was investigated for its antitussive effect on Sulfur dioxide induced cough model in mice. The extract exhibited significant antitussive activity in a dose dependant manner. The activity was compared with the prototype antitussive agent codeine phosphate. The ethanolic extract at the dose of lOOmg. 200mg and 400mg/kg body weight...
متن کاملAntitussive activity of sigma-1 receptor agonists in the guinea-pig.
1. Current antitussive medications have limited efficacy and often contain the opiate-like agent dextromethorphan (DEX). The mechanism whereby DEX inhibits cough is ill defined. DEX displays affinity at both NMDA and sigma receptors, suggesting that the antitussive activity may involve central or peripheral activity at either of these receptors. This study examined and compared the antitussive ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Japanese journal of pharmacology
دوره 17 4 شماره
صفحات -
تاریخ انتشار 1967